Plot: Leonard Hofstadter & Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, & roommates, although in all capacities their relationship is always tested primarily by Sheldons regimented, deeply eccentric, & non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz & astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman & an aspiring actress from Omaha, moves into the apartment across the hall from Leonard & Sheldons, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.